Publications in 2019

Early production of IL-17A by gammadelta T cells in the trachea promotes viral clearance during influenza infection in mice
M. Palomino-Segura, I. Latino, Y. Farsakoglu, S. F. Gonzalez
in Eur J Immunol (2019) vol. 50 pp97-109 

Characterization of the Dynamic Behavior of Neutrophils Following Influenza Vaccination
D. U. Pizzagalli, I. Latino, A. Pulfer, M. Palomino-Segura, T. Virgilio, Y. Farsakoglu, R. Krause, S. F. Gonzalez
in Frontiers in Immunology (2019) vol. 10 

Design of polymeric nanocapsules to improve their lympho-targeting capacity
J. Crecente-Campo, T. Virgilio, D. Morone, C. Calvino-Sampedro, I. Fernandez-Marino, A. Olivera, R. Varela-Calvino, S. F. Gonzalez, M. J. Alonso
in Nanomedicine (Lond) (2019) vol. 14 pp3013-3033 

Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1
M. Palomino-Segura, L. Perez, Y. Farsakoglu, T. Virgilio, I. Latino, R. D'Antuono, N. Chatziandreou, D. U. Pizzagalli, G. Wang, A. Garcia-Sastre, F. Sallusto, M. C. Carroll, O. Neyrolles, S. F. Gonzalez
in Nat Microbiol (2019) vol. 4 pp1930-1940 

Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Y. Farsakoglu, M. Palomino-Segura, I. Latino, S. Zanaga, N. Chatziandreou, D. U. Pizzagalli, A. Rinaldi, M. Bolis, F. Sallusto, J. V. Stein, S. F. Gonzalez
in Cell Rep (2019) vol. 26 pp2307-2315 e5 

Two-Photon Intravital Imaging of Leukocytes in the Trachea During Pneumococcal Infection
M. Palomino-Segura, S. F. Gonzalez
in Methods Mol Biol (2019) vol. 1968 pp183-194

In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8⁺ T Cell-Mediated Host Surveillance.
Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV.
J Immunol. 2019 Nov 1;203(9):2377-2387.

Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7.
Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF.
Int J Mol Sci. 2019 May 27;20(10).

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70.
Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF.
Front Immunol. 2019 Jan 14;9:3115.

Claudin-12 is not required for blood-brain barrier tight junction function.
Castro Dias, Mariana;  Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt.
Fluid Barriers CNS 2019 – Sep 12;16(1):30. doi: 10.1186/s12987-019-0150-9.

Claudin-3-deficient C57BL/6J mice display intact brain barriers
Castro Dias, Mariana; Caroline Coisne, Ivana Lazarevic, Pascale Baden, Masaki Hata, Noriko Iwamoto, David Miguel Ferreira Francisco, Michael Vanlandewijck, Liqun He, Felix A. Baier, Deborah Stroka, Rémy Bruggmann, Ruth Lyck, Gaby Enzmann, Urban Deutsch, Christer Betsholtz, Mikio Furuse, Shoichiro Tsukita and Britta Engelhardt.
Sci Reports 2019 Jan 18;9(1):203. doi: 10.1038/s41598-018-36731-3.

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.
Castro Dias, Mariana; Josephine A. Mapunda; Mykhailo Vladymyrov; Britta Engelhardt.
Int J Mol Sci 2019. 20(21), 5372; doi.org/10.3390/ijms20215372

Silver-containing titanium oxide nanocapsules for combating multidrug-resistant bacteria.
Hérault N*, Wagner J*, Abram SL, Widmer J, Horvath L, Vanhecke D, Bourquin C*,. Fromm M*. (*shared first and senior authorship).
International Journal of Nanomedicine, 2019, in press (JIF 4.5)

Hočevar S, Milošević A, Rodriguez-Lorenzo L, Ackermann-Hirschi L, Mottas I, Petri-Fink A, Rothen-Rutishauser B, Bourquin C*, Clift MJD* (*shared senior authorship)
Polymer-coated gold nanospheres do not impair the innate immune function of human B lymphocytes in vitro
ACS Nano, 2019, 13:6790-6800. (JIF 13.9)

Thauvin C, Widmer J, Mottas I, Hocevar S, Allémann E, Bourquin C*, Delie F* (*shared senior authorship)
Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study
Eur J Pharm Biopharm, 2019, 139:253-261. (JIF 4.6)

Mottas I*; Bekdemir A*; Cereghetti A; Spagnuolo L; Yang YS; Müller M; Irvine D; Stellacci F*; Bourquin C* (*shared first and senior authorship)
Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
Biomaterials, 2019, 190-191:111-120. (JIF 8.8)

Fico F, Bousquenaud M, Rüegg C, Santamaria-Martínez A.
Breast Cancer Stem Cells with Tumor- versus Metastasis-Initiating Capacities Are Modulated by TGFBR1 Inhibition.
Stem Cell Reports. 2019 Jul 9;13(1):1-9. Doi: 10.1016/j.stemcr.2019.05.026.

K. Ghimire, J. Zaric, B. Alday Parejo, J.  Seebac, M. Bousquenaud, G. Bieler, J. Stalin, H-J.  Schnittler and C. Ruegg.
Endothelial cell MAGI1 promotes PKA-dependent eNOS activation in response to fluid shear stress. (2019)
Cells Apr 27;8(5). pii: E388. doi: 10.3390/cells8050388.

B. Alday Parejo, R. Stupp and C. Rüegg
Are integrins still practicable targets for anti-cancer therapy? (2019).
Cancers (Basel). 2019 Jul 12;11(7). pii: E978. doi: 10.3390/cancers11070978

C. Rüegg, C. Reis, S. Rafiee, L. Rodriguez-Lorenzo, J. List, B. Rothen-Rutishauser, M. Mayer, and A. Petri-Fink.
A bioinspired amplification cascade for the detection of rare cancer cells. (2019) Chimia (Aarau). 2019 Feb
27;73(1):63-68. doi: 10.2533/chimia.2019.63.

More scientific Publications
within the framework of the PhD Program Cell Migration can be found under this link http://p3.snf.ch/project-137087